Physical Tests for Risk Evaluation Prior to Thoracoabdominal Esophageal Cancer Surgery

This is the authors' abstract. We don't add key points for this paper.

Background: Complications after esophagectomy result in higher morbidity and mortality, longer hospital stays and lower quality of life. Unfortunately, we have insufficient knowledge of which patients will tolerate major surgery. This study was designed to evaluate whether additional physical tests, apart from standard preoperative workups, could help identify high-risk patients planned for esophageal cancer surgery. Methods: A total of 88 patients due to undergo esophagectomy for esophageal cancer were enrolled. In addition to the mandatory physical examinations, seven physical tests were carried out within 10 days prior to surgery. CT scans were examined by an experienced radiologist to determine whether patients suffered from sarcopenia. Perioperative data and times of death were gathered from a national register. Associations between preoperative test performance and complications were examined. The primary outcome was the presence of any severe postoperative complication, classified as Clavien-Dindo. Secondary outcomes were several specific complications. Results: Patients with severe complications had preoperatively performed significantly worse on peak expiratory flow tests (p = 0.013). Patients suffering from anastomotic leakage had shown significantly worse performance on cardiopulmonary exercise testing, whereas the results from shoulder abduction tests were significantly lower in patients who later suffered from pneumonia (p = 0.034 and p = 0.043, respectively). Conclusion: More extensive preoperative physical examination tests could potentially aid in identifying patients with an increased risk of postoperative complications after esophageal cancer surgery.