Key result
Hypertensive diabetes is linked to ~5 mg/dl higher serum calcium levels than controls.
Why the study?
Hypertension is a major cardiovascular illness and diabetes mellitus is part of the metabolic syndrome, prompting an evaluation of serum zinc and calcium levels in hypertensive diabetic patients.
Do hypertensive diabetic patients have altered serum calcium and zinc levels compared to age- and sex-matched control subjects?
Case-Control (n=50)
No
Do hypertensive diabetic patients have altered serum calcium and zinc levels compared to age- and sex-matched control subjects?
Hypertensive diabetic patients exhibited significantly elevated serum calcium and reduced serum zinc levels compared to controls, suggesting potential trace element and electrolyte involvement in the disease pathogenesis.
Altered calcium and zinc levels in hypertensive diabetes should not yet change practice; leaves open causal roles and need for prospective trials.
Hypertension is a major cardiovascular illness worldwide with many underlying causes. Diabetic mellitus is one of the diseases of metabolic syndrome. This study was to compare the level of zinc and calcium in hypertensive diabetic. This study consisted of 25 hypertensive diabetic patients and also 25 control subjects matched for age and sex. Serum concentration of zinc was done using atomic absorption spectrophotometer while calcium estimation was achieved using colorimetric method. Result of this study was expressed as mean and standard deviation. There was a significant (p<0.05) increase in the mean values of calcium of the test group (13.8 ± 2.98 mg/dl) when compared with the control group (8.67 ± 1.19 mg/dl). Also, there was a significant decrease (p<0.05) in the mean values of zinc in test group (0.51 ± 0.37 mg/l) when compared with the control group (0.81 ± 0.26 mg/l).The result from this study revealed that hypertensive diabetic participants had low zinc and high calcium levels. The difference of these trace levels may play an important role in the pathogenesis of this disease by the involvement of these elements in the oxidative stress response.
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Glory et al. (2026) conducted a case-control in Hypertension and Diabetes Mellitus (n=50). Hypertension with comorbid diabetes mellitus vs. Age- and sex-matched control subjects was evaluated on Mean serum calcium concentration (mg/dl) (p=0.000). Hypertensive diabetic patients had significantly higher serum calcium (13.8 vs 8.67 mg/dl, p=0.000) and lower serum zinc (0.51 vs 0.81 mg/l, p=0.011) than controls.
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