Key result
Hypovitaminosis D in hypertensive patients was associated with significantly higher systolic blood pressure (155.5 vs 142.5 mm Hg) and more severe metabolic and hemodynamic disorders.
Why the study?
Low plasma levels of 25(OH)D have been associated with increased hypertension prevalence, but the association of clinical and metabolic parameters, Ca2+, and parathormone with serum 25(OH)D in hypertensive patients in the West-Ukrainian population needed evaluation.
Does low serum 25(OH)D concentration associate with worse clinical and metabolic parameters in hypertensive patients?
Case-Control (n=160)
No
Does low serum 25(OH)D concentration associate with worse clinical and metabolic parameters in hypertensive patients?
Effect estimate: 9.12% increase
Absolute Event Rate: 155.5% vs 142.5%
p-value: p=0.014
Hypovitaminosis D in hypertensive patients is associated with more severe metabolic and hemodynamic disorders, including higher blood pressure, BMI, and blood glucose.
Introduction. Low plasma levels of 25-OH vitamin D (25(OH)D) have been associated with an increased prevalence of hypertension. The purpose of the research was to establish the association of clinical and metabolic parameters, Ca2+, parathormone and serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population. Material and method. 100 subjects with essential arterial hypertension (EAH) and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. Among them, 70,84% females, 29,16% males, mean age 57,86±7,81 yo. The control group consisted of 60 healthy individuals. All recruited patients were examined for heart rate, systolic and diastolic blood pressure (SBP, DBP); SCORE, BMI, waist and hip circumference (WC, HC); lipid panel, serum glucose and ionized calcium, 25(OH)D, parathormone levels were studied. Patients were divided into groups depending on total serum 25(OH)D concentration. Results. Low 25(OH)D concentration (<30 ng/ml) in patients with EAH was associated with arrhythmia, headache, sleep disturbance, weakness, fatigue, and increased total 10-year risk for fatal CVD SCORE>5,0%. We found higher SBP and DBP by 9,12% (р=0,014) and 5,17% (р=0,047), higher BMI in men and women – by 20-28,11% (р<0,05), as well as higher values of WC and HC by 8,69-11,92% (р<0,05) in hypertensive patients with hypovitaminosis D. In addition, obesity (BMI≥30,0 kg/m2), hyperglycemia, hypertriglyceridemia was more frequent – by 43% (p<0,05), 43,13% (p<0,001) and 59,37% (p=0,023), respectively. The level of ionized Ca2+ was slightly higher in healthy individuals (p=0,047) with low vitamin D concentration. PTH was compensatory increased by 31,85% (p=0,048) in hypertensive patients with hypovitaminosis D. Conclussions. Hypovitaminosis D is associated with more severe metabolic, hemodynamic disorders and clinical symptoms in hypertensive patients in the West-Ukrainian population.
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Semianiv et al. (2021) conducted a case-control in Essential arterial hypertension (n=160). Hypovitaminosis D (<30 ng/ml) vs. Normal serum 25(OH)D concentration was evaluated on Systolic blood pressure (SBP) (9.12% increase, p=0.014). Hypovitaminosis D in hypertensive patients was associated with significantly higher systolic blood pressure (155.5 vs 142.5 mm Hg) and more severe metabolic and hemodynamic disorders.
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