Key result
Non-optimal blood pressure plus low vitamin D linked to ~2.7-fold higher incident hypertension risk.
Why the study?
Vitamin D deficiency is closely related to high blood pressure and the development of hypertension, but its relationship with blood pressure status in healthy adults and long-term hypertension development was not fully characterized.
Cohort (n=491)
No
Odds Ratio: 2.67
Absolute Event Rate: 21.1% vs 8.9%
p-value: p=<0.001
Should not yet change practice; hypothesis-generating for vitamin D supplementation trials in hypertension prevention.
Background and objectives: Hypertension is a global health problem and a major risk factor for cardiovascular diseases. Vitamin D deficiency is closely related to high blood pressure and the development of hypertension. This study investigated the relationship between the vitamin D and blood pressure status in healthy adults, and their 8-year follow-up was added. Materials and Methods: A total of 491 healthy middle-aged participants without any chronic illness, ages 21 to 67 at baseline, were divided into two groups as non-optimal blood pressure (NOBP) and optimal blood pressure (OBP). NOBP group was divided into two subgroups: normal (NBP) and high normal blood pressure (HNBP). Serum 25-hydroxy vitamin D levels were measured with the immunoassay method. 8-year follow-up of the participants was added. Results: The average vitamin D level was detected 32.53 ± 31.50 nmol/L in the OBP group and 24.41 ± 14.40 nmol/L in the NOBP group, and a statistically significant difference was found (p < 0.001). In the subgroup analysis, the mean vitamin D level was detected as 24.69 ± 13.74 and 24.28 ± 14.74 nmol/L in NBP and HNBP, respectively. Together with parathyroid hormone, other metabolic parameters were found to be significantly higher in the NOBP. During a median follow-up of 8 years, higher hypertension development rates were seen in NOBP group (p < 0.001). Conclusions: The low levels of vitamin D were significantly associated with NBP and HNBP. The low levels of vitamin D were also associated with the development of hypertension in an 8-year follow-up.
No takes yet. Share an insight, caveat, or question.
Karadeniz et al. (2021) conducted a cohort in Pre-hypertension and Vitamin D Deficiency (n=491). Non-optimal blood pressure with low vitamin D vs. Optimal blood pressure was evaluated on Development of incident hypertension at 8-year follow-up (OR 2.67, p=<0.001). Non-optimal blood pressure with low vitamin D levels was significantly associated with a higher rate of incident hypertension during an 8-year follow-up (OR 2.67, p < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: