Key result
Sokolow-Lyon yields the highest sensitivity for echocardiographic LVH at ~47%, while Romhilt-Estes is most specific.
Why the study?
Conventional ECG criteria for screening left ventricular hypertrophy may have limited sensitivity compared with direct structural assessment by echocardiography, warranting comparison of commonly used ECG criteria with echocardiographic parameters in hypertensive and non-hypertensive patients.
What is the diagnostic accuracy of conventional ECG criteria (Sokolow-Lyon, Cornell, and Romhilt-Estes) compared with transthoracic echocardiography for detecting left ventricular hypertrophy in hypertensive and non-hypertensive adults?
Cross-Sectional (n=138)
No
What is the diagnostic accuracy of conventional ECG criteria (Sokolow-Lyon, Cornell, and Romhilt-Estes) compared with transthoracic echocardiography for detecting left ventricular hypertrophy in hypertensive and non-hypertensive adults?
Conventional ECG criteria (Sokolow-Lyon, Cornell, Romhilt-Estes) have high specificity (84.6%-92.3%) but low sensitivity (10.1%-46.7%) for detecting LVH, underscoring that echocardiography remains necessary for definitive evaluation of structural left ventricular remodeling.
ECG criteria's low sensitivity cautions against sole use for LVH detection; leaves open validation of refined indices in prospective cohorts.
BACKGROUND: Left ventricular hypertrophy is an important marker of Cardiovascular risk and is commonly associated with hypertension. Electrocardiography (ECG) is widely available and inexpensive for screening LVH, but conventional ECG criteria may have limited sensitivity. Echocardiography Permits direct assessment of left ventricular structure and quantification of Left ventricular mass. OBJECTIVE: To compare commonly used ECG criteria with echocardiographic parameters for detection of LVH and to evaluate the influence of hypertension on LVH detection. METHODS: A prospective cross – sectional study was conducted among 138 adults at VELS Medical College and Hospital over 6 month period from september 2025 to February 2026. All participants underwent standard 12 – lead ECG and comprehensive transthoracic echocardiography. ECG evidence ofLVH was assessed using Sokolow – Lyon, Cornell voltage, Romhilt – estes criteria. Echocardiographic assessment included interventricular sepal thickness in diastole, left ventricular posterior wall thickness in diastole ,left ventricular internal diameterin diastole ,left ventricular mass, relative wall thickness , left ventricular ejectionfraction diastolic parameters, left atrial size, and pulmonary artery systolic pressure . participants were classified according to echocardiographic LVH status and further compared according to hypertensive status. Sensitivity, specificity, positive predictive valve, negative predictive valve, and accuracy were calculated for the ECG criteria. RESULTS: Of 138 participants, 99 had echocardiographic LVH and 39 were classified as controls.Mean age was significantly higher in the LVH group than in the control group(60.25±10.45 vs 50.00± 13.70 years; p < 0.001). hypertension was significantly more prevalent in participants with LVH than in controls( 747% vs 43.6%;p <0.001). LVM, IVSd, LVPWd, LVIDd, left atrial size, and pulmonary artery systolic pressure were higher in the LVH group,while LVEF and tissue Doppler E’ velocity were lower. Among ECG criteria, sokolow-lyon showed the highest sensitivity(46.7%) and accuracy (57.2%), whereas Romhilt – Estes demonstrated the highest specificity (92.3%). Cornell criteria showed a sensitivity of 30.3%, specificity of 89.7%, and accuracy of 47.1%. CONCLUSION: Hypertension was significantly associated with echocardiographic LVH. Conventional ECG criteria demonstrate relatively low sensitivity despite good specificity. Sokolow – lyon showed the best sensitivitry and overall accuracy, whereas Romhilt – Estes showedthe highest specificity. Echocardiography remains more useful for identification and quantification ofstructural LV remodeling, while ECG can serve asa an accessible screening tool.
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A et al. (2026) conducted a cross-sectional in Left ventricular hypertrophy in hypertensive and non-hypertensive patients (n=138). Standard 12-lead ECG criteria for LVH (Sokolow-Lyon, Cornell voltage, Romhilt-Estes) vs. Comprehensive transthoracic echocardiography was evaluated on Diagnostic accuracy of ECG criteria (Sokolow-Lyon, Cornell, Romhilt-Estes) for detection of echocardiographic LVH, and prevalence of hypertension in LVH vs controls (p=<0.001). Sokolow-Lyon ECG criteria showed the highest sensitivity (46.7%) and accuracy (57.2%) for detecting echocardiographic LVH, while Romhilt-Estes demonstrated the highest specificity (92.3%).
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