Key result
Hypertension, diabetes, and smoking are each associated with higher plasma fibrinogen levels in CHD.
Why the study?
This study aimed to compare plasma fibrinogen levels in patients with CHD according to the presence or absence of conventional cardiovascular risk factors including hypertension, diabetes mellitus, and smoking.
Does the presence of conventional cardiovascular risk factors (hypertension, diabetes mellitus, and smoking) increase plasma fibrinogen levels in patients with coronary heart disease?
Cross-Sectional (n=200)
No
Does the presence of conventional cardiovascular risk factors (hypertension, diabetes mellitus, and smoking) increase plasma fibrinogen levels in patients with coronary heart disease?
Plasma fibrinogen levels are significantly elevated in coronary heart disease patients who have hypertension, diabetes mellitus, or a history of smoking, supporting its role as an inflammatory and thrombotic biomarker for cardiovascular risk stratification.
Supports fibrinogen as risk marker in CHD; leaves open causal and prognostic validation in prospective studies.
Objective: To compare plasma fibrinogen levels in patients with coronary heart disease (CHD) according to the presence of conventional cardiovascular risk factors, namely hypertension, diabetes mellitus, and smoking. Methods: A hospital-based observational study was conducted among patients diagnosed with CHD. Plasma fibrinogen levels were measured using standard laboratory methods. Patients were categorized based on the presence or absence of hypertension, diabetes mellitus, and smoking history. Mean fibrinogen levels were compared between groups using appropriate statistical tests. Results: Among the 100 patients with coronary heart disease, fibrinogen levels were significantly higher in patients with hypertension than in non-hypertensive patients (465.31 ± 4.02 vs. 453.10 ± 4.30 mg/dL, p < 0.001). Similarly, diabetic patients had higher fibrinogen levels than non-diabetic patients (466.42 ± 3.58 vs. 454.42 ± 4.81 mg/dL, p < 0.001), while smokers showed higher levels than non-smokers (467.51 ± 3.31 vs. 455.68 ± 5.34 mg/dL, p < 0.001). Thus, elevated fibrinogen levels were significantly associated with conventional cardiovascular risk factors. Conclusion: Plasma fibrinogen levels were significantly elevated in CHD patients with hypertension, diabetes mellitus, and smoking habits. Fibrinogen may serve as an important inflammatory and thrombotic biomarker associated with conventional cardiovascular risk factors and disease severity.
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V et al. (2026) conducted a cross-sectional in Coronary heart disease (n=200). Conventional cardiovascular risk factors (hypertension, diabetes mellitus, smoking) vs. Absence of hypertension, diabetes mellitus, or smoking in patients with coronary heart disease was evaluated on Mean plasma fibrinogen concentration (mg/dL) in hypertensive vs. non-hypertensive CHD patients (p=<0.001). Hypertension, diabetes mellitus, and smoking were each associated with significantly higher plasma fibrinogen levels in patients with coronary heart disease (all p < 0.001).
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