Key result
Each 1-g/L increase in usual plasma fibrinogen level was associated with an increased risk of coronary heart disease (HR 2.42; 95% CI 2.24-2.60) in adults without prior cardiovascular disease.
Why the study?
Is plasma fibrinogen level associated with the risk of major cardiovascular diseases and nonvascular mortality in individuals without preexisting cardiovascular disease?
Meta-Analysis (n=154,211)
Yes
Is plasma fibrinogen level associated with the risk of major cardiovascular diseases and nonvascular mortality in individuals without preexisting cardiovascular disease?
Hazard Ratio: 2.42 (95% CI 2.24–2.6)
Elevated plasma fibrinogen levels are moderately strongly associated with increased risks of CHD, stroke, and mortality in healthy middle-aged adults, independent of established vascular risk factors.
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Supports fibrinogen as independent CHD risk marker; leaves open causality and therapeutic targeting.
Danesh et al. (2005) conducted a meta-analysis in Healthy adults (n=154,211). Plasma fibrinogen level vs. Lower fibrinogen levels was evaluated on Coronary heart disease (CHD) (HR 2.42, 95% CI 2.24-2.60). Each 1-g/L increase in usual plasma fibrinogen level was associated with an increased risk of coronary heart disease (HR 2.42; 95% CI 2.24-2.60) in adults without prior cardiovascular disease.
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