Key result
Each 1-g/L increase in usual plasma fibrinogen level was associated with an increased risk of coronary heart disease (HR 2.42; 95% CI 2.24-2.60) in adults without prior cardiovascular disease.
Why the study?
Is plasma fibrinogen level associated with the risk of major cardiovascular diseases and nonvascular mortality in individuals without preexisting cardiovascular disease?
Population
154,211 participants in 31 prospective studies without a previous history of cardiovascular disease.
Design
Meta-analysis
Follow-up
1.38 million person-years
Authors
Loading...
Supports fibrinogen as independent CHD risk marker; leaves open causality and therapeutic targeting.
Meta-Analysis (n=154,211)
Yes
Is plasma fibrinogen level associated with the risk of major cardiovascular diseases and nonvascular mortality in individuals without preexisting cardiovascular disease?
Hazard Ratio: 2.42 (95% CI 2.24–2.6)
Elevated plasma fibrinogen levels are moderately strongly associated with increased risks of CHD, stroke, and mortality in healthy middle-aged adults, independent of established vascular risk factors.
Danesh et al. (2005) conducted a meta-analysis in Healthy adults (n=154,211). Plasma fibrinogen level vs. Lower fibrinogen levels was evaluated on Coronary heart disease (CHD) (HR 2.42, 95% CI 2.24-2.60). Each 1-g/L increase in usual plasma fibrinogen level was associated with an increased risk of coronary heart disease (HR 2.42; 95% CI 2.24-2.60) in adults without prior cardiovascular disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: