Why the study?
Do high plasma fibrinogen levels predict fatal and/or nonfatal cardiovascular events in the general population and patients with previous cardiovascular events?
Population
General population and patients with previous cardiovascular events from 22 studies conducted between 1984…
Comparison
Plasma fibrinogen levels in the higher tertile vs Plasma fibrinogen levels in the lower tertile
Design
Meta-analysis
Authors
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High fibrinogen doubles CV event risk; reinforces independent risk marker status but leaves causal role and interventions open.
Do high plasma fibrinogen levels predict fatal and/or nonfatal cardiovascular events in the general population and patients with previous cardiovascular events?
High plasma fibrinogen is an independent risk factor for cardiovascular disease, doubling the risk of cardiovascular events in individuals in the highest tertile compared to the lowest.
Maresca et al. (1999) studied this question.
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