Key result
Plasma fibrinogen levels were significantly higher in patients with hypertension, diabetes, and both conditions compared to controls (e.g., 473.75 vs 378.95 mg/dL, P=0.001).
Cross-Sectional (n=80)
No
p-value: p=0.001
Plasma fibrinogen levels are elevated and correlate with lipid profiles in Nigerian patients with hypertension and diabetes, suggesting its potential utility as a cardiovascular risk marker.
Fibrinogen elevation may signal heightened CV risk in hypertension and diabetes; hypothesis-generating and should not yet change practice.
Background: Established markers of cardiovascular risk have become important in the evaluation of patients with diabetes and hypertension. This study correlated plasma fibrinogen with indices of cardiovascular risk in patients with type 2 diabetes, hypertension, and diabetes coexisting with hypertension. Materials and Methods: This study was cross-sectional, carried out at the Medical Outpatient (MOP) clinic of our hospital, from May to August, 2014. Eighty subjects were enrolled and were categorized into three groups, according to the following diagnoses: Diabetics, hypertensives, and patients with diabetes coexisting with hypertension. Fasting lipid profile [total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglyceride] and fibrinogen level were estimated while body mass index (BMI) was calculated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) version 20. Results were presented as means (and standard deviations), percentages, and proportions, and variables were compared using the chi-square test, analysis of variance (ANOVA), and the Pearson's correlation coefficient. The level of significance was set at P = 0.05. Results: Plasma fibrinogen levels were significantly higher in patients with hypertension, diabetes, and diabetes coexisting with hypertension than in control subjects (469.15 ± 67.99 mg/dL, 440.10 ± 45.63 mg/dL, 473.75 ± 82.61 mg/dL vs. 378.95 ± 31.37 mg/dL, respectively, P = 0.001). The total cholesterol, LDL, HDL, and BMI were significantly different in all the patient groups compared to the controls; while HDL and triglyceride correlated significantly with plasma fibrinogen in those with hypertension and diabetes coexisting with hypertension. Conclusion: Plasma fibrinogen could serve as a marker of cardiovascular risk in patients with hypertension and diabetes coexisting with hypertension.
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Chide et al. (2016) conducted a cross-sectional in Type 2 diabetes and hypertension (n=80). Hypertension and/or type 2 diabetes vs. Control subjects was evaluated on Plasma fibrinogen levels (p=0.001). Plasma fibrinogen levels were significantly higher in patients with hypertension, diabetes, and both conditions compared to controls (e.g., 473.75 vs 378.95 mg/dL, P=0.001).
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