Key result
Hypertension linked to substantially higher plasma fibrinogen and D-dimer levels versus healthy controls.
Why the study?
Hypertension causes end organ damage and can be complicated by thrombosis, prompting evaluation of fibrinogen and D-dimer levels in Sudanese hypertensive patients.
Are plasma fibrinogen and D-dimer levels elevated in Sudanese patients with hypertension compared to healthy controls?
Case-Control (n=100)
No
Are plasma fibrinogen and D-dimer levels elevated in Sudanese patients with hypertension compared to healthy controls?
Absolute Event Rate: 10.4% vs 2.8%
p-value: p=0.000
Plasma fibrinogen and D-dimer levels are significantly elevated in Sudanese hypertensive patients, suggesting a prothrombotic state associated with hypertension.
May indicate prothrombotic state in hypertension but should not change practice; leaves open need for prospective confirmation.
Background: Hypertension is a chronic elevation of blood pressure that, in the long-term, causes end organ damage and results in increased morbidity and mortality. Thrombosis often appears to complicate the course of patients with hypertension; thrombosis in some patients with hypertension could be developed to organ damage. The aim of this study was to measure fibrinogen and D-dimer level among sudanese patients with hypertension. Materials and method: This was a case control study conducted at Khartoum state, Sudan during the period from May 2022 to August 2022 to measure fibrinogen and D-dimer levels in sudanese patients with hypertension. Blood samples were collected, 50 from the patients as case group, and 50 from normal healthy subjects as control group. A total of three ml of whole blood were collected from each participant in sodium citrated tube. The fibrinogen and D-dimer level measurement was done by using coagulometer (M1 coatron) and ichroma II device respectively. Results: The results of this study revealed that when compared Fibrinogen level and D-dimer between cases and control group; the results revealed that fibrinogen level was significant increase in hypertensive patients with P-value of 0.000. Also, D-dimer was significant increase in hypertensive patients when compared with the results of control group, and showed significant association with P-value of 0.000. There was a negative correlation between hypertension and the gender, but the age showed positive correlation with hypertension and with D-dimer, where both fibrinogen and D-dimer showed positive correlation with the duration of hypertension. Conclusion: This study concluded; when compared the fibrinogen level and D- dimer between cases and control group, there was significant increase in fibrinogen and D- dimer. Keywords: Hypertension, fibrinogen level, D-dimer, coronary artery disease, ischemic heart disease, Cardiovascular disease, DIC, fibrin degradation products
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Ebar et al. (2022) conducted a case-control in Hypertension (n=100). Hypertension (Exposure) vs. Healthy controls was evaluated on Plasma fibrinogen level (g/l) (p=0.000). Hypertension was associated with significantly higher plasma fibrinogen (10.4 vs 2.8 g/l, p=0.000) and D-dimer (313.3 vs 119.6 ng/ml, p=0.000) levels compared to healthy controls.
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