Key result
Hypertension is associated with ~195% higher D-dimer levels versus healthy controls, indicating potential hypercoagulability.
Why the study?
Significant coagulation variations have been documented in hypertensive patients, motivating the evaluation of prothrombin time, activated partial thromboplastin time, and D-dimer levels in this population.
Case-Control (n=90)
Yes
Absolute Event Rate: 0.428% vs 0.145%
p-value: p=0.005
Hypertension is associated with a hypercoagulable state, evidenced by significantly elevated prothrombin time and D-dimer levels compared to healthy controls.
Hypertension was associated with elevated D-dimer; hypothesis-generating for thrombotic risk and requires prospective validation before clinical consideration.
Aim: Hypertension is typically described as a prolonged rise of systemic arterial pressure above an expected average value.Significant coagulation variations have been documented in hypertension patients.This study aims to evaluate prothrombin time, activated partial thromboplastin time, and D-Dimer levels in hypertensive patients.Material and Methods: This case-control study was conducted between March and June 2020 at Al-Daw Hagoug Hospital and Al-Turkey Hospital in Khartoum State, Sudan.The study included 90 participants: 50 patients with hypertension (blood pressure over the normal range) as the case group and 40 healthy people as the control group.After participant consent, Pt and APTT tests were performed using the (Bio base COA Semi Auto Coagulation Analyzer, Jinan, Shandong, China), and the D. Dimer test was performed using the (Nyco-Card Reader II device).Results: The most common disease duration category was 1 to 10 years.Compared to the control group, hypertension patients showed a significant (P=0.034)increase in PT and an insignificant (P=0.130)change in APTT.The results show a significant difference in PT (P=0.029) between the HTN and HTN combined Diabetes Mellitus (DM) groups.D-dimer levels were significantly higher (P=0.005) in hypertension patients than in the control group.Discussion: The study assumed that hypertension had an adverse influence on hemostatic parameters and could lead to a hypercoagulable state.
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Husham O. Elzein (2024) conducted a case-control in Hypertension (n=90). Hypertension (Exposure) vs. Healthy normotensive individuals was evaluated on D-dimer levels (mg/l) (p=0.005). Hypertensive patients exhibited significantly higher D-dimer levels (0.428 mg/l) compared to healthy controls (0.145 mg/l, P=0.005), indicating a potential hypercoagulable state.
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