Key result
CVD in type 2 diabetes linked to significantly higher BMI, glucose, and insulin levels.
Why the study?
Are plasma levels of glucose, HbA1c, insulin, and lipid profile altered in Sudanese T2DM patients with cardiovascular disease compared to those without?
Case-Control (n=330)
Are plasma levels of glucose, HbA1c, insulin, and lipid profile altered in Sudanese T2DM patients with cardiovascular disease compared to those without?
Answers are grounded in this paper and cite their sources.
Sudanese T2DM patients with cardiovascular disease have significantly higher BMI, fasting blood glucose, HbA1c, HDL-C, and insulin levels compared to those without cardiovascular disease.
<ns4:p> <ns4:bold>Background:</ns4:bold> Type 2 diabetes mellitus (T2DM) and its consequences are a serious global public health issue. By 2030, the number of people with type 2 diabetes is predicted to reach 439 million. The purpose of this study is to evaluate the plasma levels of glucose, HbA1c, insulin, and lipid profile in Sudanese T2DM patients. <ns4:bold>Methods:</ns4:bold> This case control study included 165 Sudanese patients with diabetic type 2 and a cardiovascular condition as cases and 165 diabetic type 2 volunteers without a cardiovascular disorder as controls. The concentrations of plasma glucose, HbA1c, and lipid profile were assessed using a Mindray BS-480 auto-chemistry analyzer, and insulin was analyzed using a Cobase 411 auto analyzer. The collected data were analyzed using statistical tools for social science computer programs (SPSS version 21). <ns4:bold>Results:</ns4:bold> According to the findings, (59.4%) of patients between the ages of (50-69). Females made up 50.9%. (38.2%) of patients had an illness duration of between (8-15 years). (41.8%) of individuals did not have hypertension. There was a substantial rise in BMI, FBG, HbA1c, HDL-C, and insulin among diabetics with cardiovascular disease compared to diabetics without cardiovascular disease (p-value = 0.001, 0.000, 0.018, and 0.000). Females had significantly higher blood TC, LDL-C, HDL-C, and BMI than males (p-values = 0.000, 0,001, and 0.000, respectively). There were significant positive correlation between FBS, HBA1c, insulin and duration of disease (r=0.155, p, value=0.005) (r=0.160, p, value=0.004)(r=0.103, p. value=0.061)respectively, while there were significant negative correlation between TC, TG,LDL-C, HDL-C and duration of disease (r=-0.152, p, value= 0.006)(r=-0.023, p, value=0.678)(r=-0.113, p, value= 0.040)(r=-0.145, p, value=0.008)respectively. <ns4:bold>Conclusion:</ns4:bold> When comparing diabetics with cardiovascular disease to diabetics without cardiovascular disease, there was a substantial rise in BMI, FBG, HbA1c, HDL-C, and insulin. FBS, HBA1c, insulin, and illness duration all had a strong positive connection. </ns4:p>
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Abdallah et al. (2024) conducted a case-control in Type 2 diabetes mellitus with cardiovascular disease (n=330). Cardiovascular disease vs. No cardiovascular disease was evaluated on Plasma levels of BMI, FBG, HbA1c, HDL-C, and insulin (p=0.001, 0.000, 0.018, and 0.000). Type 2 diabetic patients with cardiovascular disease had significantly higher BMI, fasting blood glucose, HbA1c, HDL-C, and insulin compared to those without cardiovascular disease.
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