Key result
Hypertension was associated with significantly higher prothrombin time and activated partial thromboplastin time compared to normotensive subjects (P < 0.05).
Why the study?
Are prothrombin time and activated partial thromboplastin time altered in hypertensive patients compared to normotensive subjects?
Cross-Sectional (n=81)
No
Are prothrombin time and activated partial thromboplastin time altered in hypertensive patients compared to normotensive subjects?
p-value: p=<0.05
Hypertension is associated with prolonged prothrombin time and activated partial thromboplastin time, indicating potential hemostatic abnormalities.
Introduction. Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension. Methods. This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar. Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods. Results. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r = 0.3072, r = 0.4988; P < 0.05) in hypertensive patients. DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P < 0.05). DBP correlated negatively with duration of illness (r = -0.3097; P < 0.05) in hypertensive patients and positively with age of normotensive subjects (r = 0.3523; P < 0.05). Conclusion. The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy. However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays.
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Adaeze et al. (2014) conducted a cross-sectional in Hypertension (n=81). Hypertension vs. Normotensive subjects was evaluated on Prothrombin time (PT) and activated partial thromboplastin time (APTT) (p=<0.05). Hypertension was associated with significantly higher prothrombin time and activated partial thromboplastin time compared to normotensive subjects (P < 0.05).
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