Key result
Coronary microcirculatory dysfunction drives microvascular angina through endothelial dysfunction, inflammation, and vascular remodeling.
Why the study?
Microvascular angina involves a complex pathogenesis of coronary microcirculatory dysfunction and presents diagnostic and treatment difficulties.
This clinical lecture outlines the complex pathogenesis, clinical manifestations, and diagnostic and treatment approaches for microvascular angina.
Clinical lecture on microvascular angina pathogenesis leaves open targeted therapy development; prospective trials needed before practice change.
Microvascular angina is a form of ischemic heart disease in which myocardial ischemia is not associated with significant stenosis of the epicardial coronary arteries and is caused by dysfunction of the coronary microcirculatory bed. The disease is characterized by a complex pathogenesis, including endothelial dysfunction, inflammation, vascular remodeling, and metabolic disturbances. This clinical lecture presents the pathogenesis associated with morphological and functional changes in the microvessels and myocardium, clinical manifestations, modern approaches to diagnosis and treatment, and principles of clinical diagnosis.
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Nifontov et al. (2026) conducted a review in Microvascular angina. Microvascular angina is caused by coronary microcirculatory dysfunction without significant epicardial stenosis and involves endothelial dysfunction, inflammation, and vascular remodeling.
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