Mecanotransducción Somatosensorial Precordial: Validación Paramétrica del Protocolo Bimodal IC-H para la Síntesis de Oxitocina y Modulación de la Conectividad Amigdalina

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Background: Cutaneous and periosteal mechanobiology demonstrates that tactile afferents modulate autonomic centers and neuroendocrine pathways under structured mechanical loading. Objective: This short communication provides a reverse-engineering validation of the precordial and esternal nodes within the unified Human Cognitive Engineering (IC-H) framework, optimized for on-demand Oxytocin biosynthesis and amygdalinar down-regulation. Methods: The protocol integrates an ionic-protonic-lipidic priming phase (500 mL H2O + 1.5 g NaCl + citric acid + 10 mL Extra Virgin Olive Oil [EVOO]). After 20 minutes, a bimodal mechanical sequence (35 s micro-percussion @ 2.1 Hz, 4 prolonged respiratory cycles, and 10 s terminal static compression) is applied to high-density pericranial and somatic anchors, specifically targeting the manubrium sterni and the precordial fascia under a unified force baseline of 1.0–1.5 N. Results: Molecular models confirm that oleic acid from EVOO inserts into lipid bilayers, reducing lateral packing stress and decreasing the mechanical threshold of stretch-activated Piezo2 channels. The 1.5 g NaCl priming expands the local hyaluronic acid matrix, establishing a non-compressible hydrostatic cushion (0.499) that directs the acoustic shear waves from the 2.1 Hz micro-percussion into the periosteal unmyelinated C-tactile (CT) fibers. Intracellular Ca2+ fluxes trigger forward action potentials through the spinothalamic tract, making monosynaptic projections to the paraventricular (PVN) and supraoptic (SON) hypothalamic nuclei, driving systemic and central Oxytocin exocytosis. Centrally, Oxytocin binds to OXTR receptors on amygdalinar GABAergic interneurons, inducing a robust post-synaptic hyperpolarization that dampens the autonomic flight-or-fight response. Peripheral mechanoreceptors (Ruffini endings) maintain tonic activation during the terminal static phase, promoting cardiac coherence via respiratory sinus arrhythmia (RSA) upregulation. Conclusion: This unified biomechanical window acts as an exact, non-pharmacological switch for neuro-affective stabilization.