Key result
Family history is linked to ~4.6-fold higher hypertension odds in schizophrenia patients.
Why the study?
Schizophrenia is associated with increased cardiovascular risk and reduced life expectancy due to hypertension, but data on the prevalence and associated factors of hypertension among patients with schizophrenia in Bangladesh are scarce.
Cross-Sectional (n=60)
No
Hypertension affects 18.3% of schizophrenia patients in this Bangladeshi cohort, with over half (54.5%) being newly diagnosed, underscoring a critical need for routine blood pressure screening and integrated physical health monitoring in psychiatric care.
May support BP screening in schizophrenia; leaves open whether targeting these predictors improves outcomes.
Schizophrenia is associated with increased cardiovascular risk and reduced life expectancy, with hypertension being a major contributor. However, data on the prevalence of hypertension among schizophrenia patients in Bangladesh is scarce. To determine this and to identify the associated factors among patients with schizophrenia attending a tertiary psychiatric hospital in Sylhet, Bangladesh, this cross-sectional study was conducted from 1st July, 2025 to 31st December, 2025. A total of 60 patients diagnosed with schizophrenia according to DSM-5 criteria, aged ≥18 years were enrolled using convenience sampling. Data were collected through interviews, medical record review, anthropometric measurements, and blood-pressure assessment. Hypertension was defined as systolic BP ≥140 mmHg and/or diastolic BP ≥ 90 mmHg on at least two occasions or on the basis of ongoing antihypertensive medication. Data were analyzed using SPSS version 26.0; chi-square test and binary logistic regression were applied. The mean age of participants was 32.9±11.4 years, with male predominance (60%). The prevalence of hypertension among schizophrenia patients was found to be 18.30%. Among hypertensive patients, 54.50% were newly diagnosed as such. Chronic schizophrenia was the most common type (70%). Risperidone was the most frequently prescribed antipsychotic (61.7%). Amlodipine was the commonest prescribed antihypertensive (80%). Multivariate analysis identified increasing age (OR=1.08, 95% CI: 1.01-1.16), higher BMI (OR=1.23, 95% CI: 1.03-1.47), and family history of hypertension (OR=4.57, 95% CI: 1.14-18.36) as independent predictors. Hypertension affects nearly one-fifth of schizophrenia patients, with over half being newly diagnosed, highlighting a critical gap in routine cardiovascular screening. Age, BMI, and positive family history showed significant association with hypertension. Incorporation of integrated physical health monitoring into standard psychiatric care is recommended. Bang J Psychiatry 2025;39(2): 34-40
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Sayed et al. (2026) conducted a cross-sectional in Schizophrenia (n=60). Family history of hypertension vs. No family history of hypertension was evaluated on Prevalence of hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg on at least two occasions or ongoing antihypertensive medication) (OR 4.57, 95% CI 1.14-18.36, p=0.032). Hypertension affected 18.3% of schizophrenia patients (54.5% newly diagnosed), with family history (OR 4.57), higher BMI (OR 1.23), and age (OR 1.08) as independent predictors.
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