Key result
PCI within 12 hours of STEMI yielded lower heart rate increases during final inpatient rehab vs delayed (>12h) or no PCI (21.4 vs 24.6 vs 26.9 bpm, p<0.001).
Why the study?
Cardiac rehabilitation is a key element of treating acute myocardial infarction, and its benefits are influenced by infarction location and the timing of primary percutaneous coronary intervention.
Does the timing of percutaneous coronary intervention and the anatomical location of myocardial infarction influence short-term hemodynamic responses and perceived exertion during an early 4-day inpatient cardiac rehabilitation program in patients with STEMI?
Observational (n=111)
No
Does the timing of percutaneous coronary intervention and the anatomical location of myocardial infarction influence short-term hemodynamic responses and perceived exertion during an early 4-day inpatient cardiac rehabilitation program in patients with STEMI?
In STEMI patients undergoing early 4-day inpatient cardiac rehabilitation, those revascularized via PCI within 12 hours and those with inferior MI exhibit superior hemodynamic adaptation and lower perceived exertion compared to patients with delayed/no PCI or anterior MI.
Early PCI timing was associated with better inpatient rehab tolerance after STEMI; leaves open effects on clinical outcomes pending randomized trials.
Background Cardiac rehabilitation is a key element of the multidisciplinary approach to treating patients with acute myocardial infarction. The location of the infarction and the timing of primary percutaneous coronary intervention influence the benefits of rehabilitation. Material and methods An early rehabilitation program was implemented for 111 patients with ST-segment elevation myocardial infarction, both with and without primary percutaneous coronary intervention. The study involved an analysis of heart rate, systolic blood pressure, and subjective ratings of physical exertion. Results Patients who underwent percutaneous coronary intervention within the first 12 hours of the infarction demonstrated the most favorable physical response to exertion throughout the program sessions. Statistically significant differences were observed primarily in heart rate values and subjective ratings of exertion. Patients with inferior myocardial infarction showed a better physical response regarding the studied parameters compared to those with anterior myocardial infarction. Conclusions Regardless of the treatment method, the implementation of an early rehabilitation program involving a gradual increase in exercise intensity is safe and effective and is recommended for all patients.
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Megova et al. (2026) conducted an observational in ST-segment elevation myocardial infarction (n=111). Early percutaneous coronary intervention (≤12 hours) during inpatient cardiac rehabilitation vs. Late percutaneous coronary intervention (>12 hours) or no PCI was evaluated on Mean increase in heart rate from resting values during the final (6th) rehabilitation session (beats/min) (p=<0.001). PCI within 12 hours of STEMI yielded lower heart rate increases during final inpatient rehab vs delayed (>12h) or no PCI (21.4 vs 24.6 vs 26.9 bpm, p<0.001).
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