Key result
eGFR shows no independent association with local carotid pulse wave velocity.
Why the study?
Kidney dysfunction has been associated with arterial stiffening, but the relationship may depend on shared cardiometabolic and haemodynamic factors. This study examined the association between eGFR and local carotid arterial stiffness in adults with a high prevalence of diabetes and hypertension.
Cross-Sectional (n=135)
No
In a cardiometabolic risk population with largely preserved kidney function, local carotid arterial stiffness is driven by age, diabetes, and blood pressure rather than eGFR.
No independent eGFR–PWVβ link observed; leaves open renal contributions to arterial stiffness in diabetes–hypertension.
Background and Objectives: Kidney dysfunction has been associated with arterial stiffening, but the relationship may depend on shared cardiometabolic and haemody-namic factors. This study examined the association between estimated glomerular fil-tration rate (eGFR) and local carotid arterial stiffness in adults with a high prevalence of diabetes and hypertension. Materials and Methods: This single-centre cross-sectional study included 135 adults. Local carotid pulse wave velocity derived from the beta stiffness index (PWVβ) was the primary outcome. Secondary outcomes were the beta stiffness index, pressure–strain elastic modulus, arterial compliance, and augmentation index. Multivariable linear regression evaluated associations with eGFR, age, sex, dia-betes, and hypertension. Separate models replaced hypertension status with peripheral or central aortic systolic blood pressure. Results: Mean age was 57.4 ± 7.4 years, and mean eGFR was 83.3 ± 20.0 mL/min/1.73 m². PWVβ differed across the four diabetes–hypertension groups (p < 0.001). In the primary model, based on 117 participants, higher PWVβ was associated with age, diabetes, and hypertension. There was no evidence of an independent association between eGFR and PWVβ (B = −0.003 per mL/min/1.73 m²; 95% confidence interval, −0.014 to 0.009; p = 0.676). eGFR was also not associated with the secondary outcomes. Peripheral and central aortic systolic blood pressure were positively associated with PWVβ in separate adjusted models. Conclusion: In this cardiometabolic risk population, eGFR was not independently associated with local carotid arterial stiffness. Age, diabetes, and blood pressure were associated with higher PWVβ. The findings concern contemporaneous associations and should not be extrapolated to ad-vanced chronic kidney disease or interpreted as excluding a longitudinal relationship between kidney function and vascular stiffness.
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Marinova et al. (2026) conducted a cross-sectional in Cardiometabolic risk (high prevalence of diabetes and hypertension) (n=135). Estimated glomerular filtration rate (eGFR) was evaluated on Local carotid pulse wave velocity derived from the beta stiffness index (PWVβ) (B -0.003 per mL/min/1.73 m², 95% CI -0.014 to 0.009, p=0.676). Estimated glomerular filtration rate was not independently associated with local carotid pulse wave velocity (B = -0.003 per mL/min/1.73 m²; 95% CI -0.014 to 0.009; p = 0.676).
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