Salmonella enteritidis-Associated Pericarditis in an Immunocompetent Individual

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Salmonella enteritidis-associated pericarditis (n=1). Intervention: Intravenous ciprofloxacin and oral ibuprofen. Primary outcome: Clinical, biochemical, and electrocardiographic resolution of pericarditis and bacteremia.

Seval SÖNMEZ YILDIRIM; Oğuz Yıldırım

doi:10.5578/flora.2026031605

October 13, 2026Flora the Journal of Infectious Diseases and Clinical MicrobiologyOpen Access

Salmonella enteritidis-Associated Pericarditis in an Immunocompetent Individual

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Key Points

To describe the clinical presentation, diagnosis, and successful treatment of rare Salmonella enteritidis pericarditis in an immunocompetent individual.
Clinical, laboratory, electrocardiographic, and microbiological evaluation of a 22-year-old man presenting with chest pain and intermittent fever following a diarrheal illness.
Initial laboratory evaluation revealed a troponin T level of 2.600 pg/mL (reference range 0–24.9 pg/mL), C-reactive protein of 51.28 mg/L, creatine kinase–MB of 32 U/L, and concave ST-segment elevations of less than 5 mm in leads I, aVL, and V2–V5.
Blood cultures isolated Salmonella enteritidis, while testing for viral pathogens including EBV, CMV, parvovirus B19, influenza, and SARS-CoV-2 was negative.
Targeted antimicrobial therapy led to the resolution of fever, chest pain, and electrocardiographic abnormalities, with troponin T levels decreasing by day 3 of therapy prior to discharge after four weeks of treatment.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P

Population

1 immunocompetent 22-year-old man with no history of cardiac disease presenting with Salmonella enteritidis-associated pericarditis, treated and followed for 4 weeks.

I

Intervention

Ibuprofen 1.200 mg/day for one week and targeted antibiotic therapy for four weeks

O

Outcome

Resolution of fever and chest pain, decrease in troponin T levels, clearance of bacteremia on follow-up blood cultures, and normalization of electrocardiographic ST-segment elevations by the end of four weeks of treatment

This case report highlights that non-typhoidal Salmonella enteritidis can cause acute pericarditis with marked troponin elevation even in young, immunocompetent individuals, successfully managed with a 4-week course of targeted antibiotics and short-term ibuprofen.

Limitations

Single patient case report
Testing for Coxsackievirus could not be performed because of resource limitations
Direct bacterial invasion of myocardial tissue was not demonstrated

Implication

May support combined therapy in rare bacterial pericarditis; leaves open confirmation in prospective studies.

Abstract

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Cite This Study

YILDIRIM et al. (2026) conducted a case report in Salmonella enteritidis-associated pericarditis (n=1). Intravenous ciprofloxacin and oral ibuprofen was evaluated on Clinical, biochemical, and electrocardiographic resolution of pericarditis and bacteremia.

synapsesocial.com/papers/6ae28f42cbadf70daf6c4486 https://doi.org/10.5578/flora.2026031605

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Salmonella enteritidis-Associated Pericarditis in an Immunocompetent Individual

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Salmonella enteritidis-Associated Pericarditis in an Immunocompetent Individual

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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