Hypomagnetic Exposure and Hemodynamic Response: Macro - To Microscale

This is the authors' abstract. We don't add key points for this paper.

This article presents the results of a study devoted to investigating the effects of hypomagnetic conditions (HMC) on macro‑ and microhemodynamics in humans under simulated prolonged isolation. Microcirculation parameters and autonomic regulation were assessed in a group of 6 healthy volunteers (2 males and 4 females) within the SIRIUS project, using laser Doppler flowmetry and heart rate variability analysis. HMC were simulated by reducing the geomagnetic field by a factor of 350 with specialized system “Arfa”. Under HMC, a decrease in parasympathetic activity (reduced pNN50 and MxDMn values), an increase in sympathetic activity, and elevated heart rate and blood pressure were observed. At the level of skin microcirculation an increase in the amplitude of endothelial and neurogenic oscillations was noted, alongside a decrease in the amplitude of venular and pulse oscillations. It was found that HMC trigger activation of the sympathoadrenal system and alter microcirculation regulatory mechanisms. The obtained data suggest a potential increase in oxidative stress under reduced geomagnetic field conditions, which may pose health risks during long-duration spaceflights.