Natural products occupy chemically diverse and often sparsely annotated regions of bioactive chemical space, where a single target assay can capture only a narrow fraction of their cellular effects. High-content phenotypic imaging offers a complementary strategy by representing drug-induced cellular responses as multidimensional morphological signatures that can be searched, compared and modeled computationally. This conceptual framework examines how natural-product chemistry can be connected to
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Silva et al. (2025) studied this question.
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