Answers are grounded in this paper and cite their sources.
Examples from our group on the use of organic synthesis as a scientific method are presented. Challenges regarding the constitution and configuration of natural products, their biological activity, the feasibility of biosynthetic transformations, the role of putative intermediates in biosynthetic pathways, and the role of substituents in toxic compounds have been investigated by the preparation of synthetic natural products and their derivatives.
No takes yet. Share an insight, caveat, or question.
Karl Gademann (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: