Background: MicroRNA-146 (miR-146a/b) regulates inflammatory pathways, including Nuclear Factor-kappa B (NF-κB) signaling, and is implicated in asthma pathogenesis, though expression patterns vary across studies.This systematic review synthesizes evidence on miR-146's expression, clinical relevance, and diagnostic potential in asthma.Methods: Following PRISMA guidelines, a systematic review of Scopus, Web of Science, and PubMed identified 285 records.Methodological quality was assessed using the Newcastle-Ottawa Scale for observational studies and the SciRAP tool for in vitro studies.Results: After screening, 22 studies (2012-2023) involving pediatric and adult populations were included in the final analysis.miR-146a exhibited a tissue-specific bimodal pattern in asthma patients: upregulated in circulation (plasma/serum) in allergic or mild-moderate asthma, but
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Shojaei et al. (2026) studied this question.
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