Key result
Elevated serum Cystatin C in hemoglobinopathies does not correlate with left ventricular strain.
Why the study?
Cardiac problems are a primary cause of morbidity and mortality in patients with sickle cell anaemia and thalassemia. Whether serum Cystatin C can serve as an early determinant of subclinical cardiovascular dysfunction in these adult patients was uncertain.
Does serum Cystatin C correlate with subclinical left ventricular dysfunction (measured by global longitudinal strain) in adults with sickle cell anaemia and beta-thalassemia?
Case-Control (n=123)
No
Does serum Cystatin C correlate with subclinical left ventricular dysfunction (measured by global longitudinal strain) in adults with sickle cell anaemia and beta-thalassemia?
Although serum Cystatin C is elevated and left ventricular global longitudinal strain is impaired in adults with sickle cell anaemia and beta-thalassemia, Cystatin C does not correlate with subclinical myocardial strain dysfunction in these patients.
Answers are grounded in this paper and cite their sources.
Serum cystatin C should not guide subclinical LV dysfunction assessment in hemoglobinopathies; leaves open prospective biomarker validation.
Background Haemoglobinopathies, such as thalassemia and sickle cell anaemia (SCA), are inherited conditions caused by abnormal haemoglobin production. Cardiac problems are among the primary factors contributing to illness and death in these individuals. Cystatin C in humans is a reliable indicator of glomerular filtration rate and may also indicate cardiovascular disease risk, even without chronic renal conditions. We aim to evaluate whether Cystatin C can be used as an early determinant of cardiovascular problems in adult cases with sickle cell anaemia and thalassemia. Methods This study included 41 adults with sickle cell anaemia, 41 patients with B thalassemia, and 41 age and sex-matched controls with clinical and laboratory assessments including complete blood count, Cystatin C, and pro B-type natriuretic peptide, kidney and liver functions. Radiological assessment is done using 2D echocardiography and speckle tracking to detect subtle ventricular dysfunction. Results There was no correlation between Cystatin C level and global longitudinal strain echocardiography in patients with sickle cell anaemia and thalassemia. However, there was a significant variation was observed in the global longitudinal strain of the left ventricle between the sickle cell anaemia cases and thalassemia versus the controls ( P < 0.05). Cystatin C levels were higher among the cases when compared to the controls. Conclusion There was no correlation between Cystatin C and the left ventricular global longitudinal strain of sickle cell anaemia and thalassemia.
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Mohammed et al. (2025) conducted a case-control in Sickle cell anemia and beta-thalassemia (n=123). Serum Cystatin C in sickle cell anemia and beta-thalassemia vs. Healthy age- and sex-matched controls was evaluated on Correlation between serum Cystatin C and left ventricular global longitudinal strain (LVGLS), and comparison of Cystatin C levels across groups (r = -0.275 (SCA Cystatin C vs GLS), p=<0.001). Serum Cystatin C was higher in sickle cell anemia and thalassemia vs controls, but did not correlate with left ventricular global longitudinal strain.
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