Key result
Microtubules drive cardiomyocyte hypertrophy and remodeling by altering translation and intercellular adhesion.
Design
Review
Does not yet warrant changes in clinical practice; leaves open microtubule targeting for future remodeling trials.
Past research has long hinted at a connection between microtubules and the growth of the heart. Here, we highlight a new role for microtubules in directing cardiomyocyte hypertrophy by altering protein translation and intercellular adhesion and discuss how these findings illuminate open questions in cardiac remodeling.
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Scarborough et al. (2026) studied this question. Microtubules direct cardiomyocyte hypertrophy and cardiac remodeling by altering protein translation and intercellular adhesion.
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