Key result
Microtubule cytoskeletal networks mediate cardiomyocyte mechanobiology and are linked to cardiac disease phenotypes.
Why the study?
The role of microtubules in cardiomyocyte mechanobiology, especially their coordination with other cytoskeletal elements and connection to cardiac disease phenotypes, is essential but often understated.
Provides a comprehensive overview of the role of the microtubule cytoskeletal network in cardiomyocyte mechanobiology and its implications in cardiac disease.
Highlights microtubule roles in cardiac mechanobiology; leaves open targeted interventions in disease.
The intracellular cytoskeletal network is a central mediator of mechanobiology, transmitting extracellular cues from the cell membrane to elicit downstream changes in cell behaviour and morphology. In cardiomyocytes, mechanotransduction via the intracellular cytoskeleton plays a pivotal role in regulating cardiac output, development and pathological remodelling. Various structural components contribute to this process, including tension-mediated ion channels, contractile sarcomere units, transmembrane cell junction proteins, intermediate filaments and the microtubule network. Among these components, microtubules are the largest and most rigid cytoskeletal elements. This Review highlights the essential, but often understated, role of microtubules in cardiomyocyte mechanobiology, particularly in their coordination with other cytoskeletal elements. Furthermore, this Review highlights how the microtubule cytoskeletal network is connected to cardiac disease phenotypes.
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Li et al. (2026) conducted a review in Cardiac disease. Microtubule cytoskeletal network was evaluated. The microtubule cytoskeletal network plays an essential role in cardiomyocyte mechanobiology and is connected to cardiac disease phenotypes.
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