Key result
Serum nitric oxide levels vary across ethnic groups but show no association with hypertension.
Why the study?
Disrupted nitric oxide (NO) production and bioavailability contribute to endothelial dysfunction in hypertension, motivating evaluation of serum NO levels across three ethnic groups in Aceh to assess its role in hypertension pathogenesis.
Observational (n=120)
Yes
Although serum nitric oxide metabolite levels varied significantly among the Gayo, Aneuk Jamee, and Acehnese ethnic groups in Aceh, these variations were not significantly correlated with the presence of hypertension when compared to normotensive controls.
Answers are grounded in this paper and cite their sources.
Ethnic nitric oxide differences should not inform hypertension risk assessment; hypothesis-generating for ethnic determinants requiring prospective validation.
Hypertension is a global health problem, affecting an estimated 1.4 billion people worldwide. The pathophysiology of hypertension is multifactorial and involves complex mechanisms, one of which is endothelial dysfunction, marked by disruption of NO production and its bioavailability. NO is a key modulator of vasodilation that takes part in controlling vascular homeostasis. This research aims to evaluate NO serum among three ethnicities in Aceh to assess its role in hypertension pathogenesis. This observational analytic research included 120 participants, comprising 90 hypertensive patients from three ethnic groups (Gayo, Aneuk Jamee, and Acehnese), with 30 participants in each ethnic group, and 30 normotensive individuals who served as the control group. The NO serum level among their ethnicities was analysed by the Kruskal-Wallis test, while the association between NO levels across three ethnicities and the control group (not hypertensive patients) was assessed by the Spearman test. The study found that the Gayo group had the highest NO level (51.79 pg/mL), followed by Aneuk Jamee (44.27 pg/mL) and the Acehnese group (31.87 pg/mL), with significant differences (p<0.001). The correlation analysis showed a weak relation, both across the three ethnic groups and when compared to the control group (p>0.05). Serum nitric oxide (NO) levels differ significantly among ethnic groups; however, no significant association was observed between ethnic groups and the incidence of hypertension.
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Gunawan et al. (2026) conducted an observational in Hypertension (n=120). Ethnicity (Gayo vs Aneuk Jamee vs Acehnese) in hypertension vs. Acehnese ethnic group and normotensive controls was evaluated on Mean serum nitric oxide (NO) level (µmol/L) across ethnic groups (p=<0.001). Serum nitric oxide levels differed significantly across ethnic groups (Gayo 51.79 vs Aneuk Jamee 44.27 vs Acehnese 31.87 µmol/L, p<0.001), with no correlation to hypertension (p>0.05).
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