Feature selection (FS) can improve prediction, while searching many combinations of selectors, subset sizes, and classifiers adds substantial cost. We predict the dataset-level AUC gain from the best combination in this FS-enabled portfolio over the best all-feature classifier. Among 99 datasets in the prediction sample, 51 show any positive gain and five gain at least 0.04 absolute AUC points. A class-weighted Random Forest using five basic descriptors and 21 Problexity measures achieves leave-one-dataset-out AUROC of 0.722 for any positive gain and 0.708 for gains of at least 0.04. Matched random-subset searches and outer-fold tests provide complementary evidence on search utility. SHAP analysis identifies neighborhood structure, feature overlap, and dataset size as influential predictors. These results support dataset-level prioritization of FS portfolio search and identify directions for strengthening its predictive precision.
No takes yet. Share an insight, caveat, or question.
Elmakias et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: