Statistical design of Path to Prevention platform trial in early neuronal alpha-synuclein disease

The shared code supports the simulations, analyses, and results in the article "Statistical design of Path to Prevention platform trial in early neuronal alpha-synuclein disease". Data used in the preparation of this article were obtained on 2025-09-29 from the Parkinson’s Precision Medicine Initiative (PPMI) database (RRID:SCR_006431). For up-to-date information on the study, visit http://www.ppmi-info.org. As the PPMI database is always evolving, it is possible that the code may not work if the database has changed since the date the code was created. Analytic datasets are not included in the submission. Researchers can request access to PPMI data at the PPMI Study website (https://www.ppmi-info.org/access-data-specimens/download-data).