Key result
Poor blood pressure control linked to ~2.7-fold higher 5-year risk of renal insufficiency.
Why the study?
Although hypertension is a leading global driver of CKD progression, the extent to which long-term blood pressure control modifies the incidence of renal insufficiency in routine clinical practice remained incompletely characterized.
Does sustained blood pressure control (<140/90 mmHg) reduce the incidence of renal insufficiency and slow eGFR decline compared to poor blood pressure control in hypertensive adults aged 40-80 years?
Cohort (n=1,000)
Does sustained blood pressure control (<140/90 mmHg) reduce the incidence of renal insufficiency and slow eGFR decline compared to poor blood pressure control in hypertensive adults aged 40-80 years?
In hypertensive adults followed for five years, poor blood pressure control was associated with a nearly threefold increased risk of developing renal insufficiency and a more than tripled rate of annual eGFR decline compared to sustained blood pressure control below 140/90 mmHg.
Supports observational BP-renal link in routine care; leaves open causal effects pending randomized confirmation.
Hypertension is a leading global driver of chronic kidney disease (CKD) progression, yet the extent to which long‑term blood pressure (BP) control modifies the incidence of renal insufficiency in routine clinical practice remains incompletely characterized [1]. This retrospective cohort study compares hypertensive adults with sustained BP control to those with persistently elevated values over a five‑year follow‑up. Patients with poor BP control exhibited a markedly higher incidence of renal insufficiency and a steeper decline in estimated glomerular filtration rate (eGFR), consistent with known mechanisms of hypertensive nephropathy [2]. These findings reinforce the central role of BP management in preventing CKD progression and highlight the need for sustained therapeutic adherence [3].
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Duranti et al. (2026) conducted a cohort in Hypertension (n=1,000). Poor blood pressure control (persistently elevated BP, mean 152/96 mmHg) vs. Good blood pressure control (BP consistently <140/90 mmHg, mean 132/82 mmHg) was evaluated on Incidence of renal insufficiency (confirmed eGFR <60 mL/min/1.73 m² persisting for >=3 months or >=30% decline in eGFR from baseline) (RR 2.69, 95% CI 2.01-3.45). Poor blood pressure control increased the 5-year incidence of renal insufficiency compared to good control (22.6% vs 8.4%; RR 2.69, 95% CI 2.01-3.45).
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