Key result
Antihypertensive therapy is linked to suspected adverse drug reactions in ~7% of patients.
Why the study?
The study aimed to evaluate adverse drug reactions, drug-related problems, treatment patterns, and outcomes in patients with hypertension at a tertiary care hospital in Lucknow.
Cross-Sectional (n=100)
No
This hospital-based observational study highlights the occurrence of preventable drug-related problems (such as failure to receive medication and drug-drug interactions) and classic adverse drug reactions (dry cough, pedal edema, hyperkalemia) in hypertensive patients, underscoring the need for routine pharmacovigilance and rational prescribing.
Objective: The primary goal of the study was to evaluate adverse drug reactions and drug-related problems in patients with hypertension at the tertiary care hospital in Lucknow. The secondary goal was to assess the treatment patterns and outcomes for these patients at the same hospital. Material and Methods: This was a prospective, observational study. A total of 100 patients who met the inclusion and exclusion criteria were recruited from the general medicine division's outpatient and inpatient departments at the Integral Institute of Medical Science and Research Hospital. Patients’ data were evaluated to identify Drug-Related Problems using a systematic, evidence-based approach. Results: Data from 100 patients were collected in this study. The main identified drug-related problems affecting blood pressure control included failure to receive medications, drug-drug interactions, and untreated indications. A total of 3 Adverse Drug Reactions (ADRs) were observed among the 100 cases. Hyperkalemia was observed in 02 patients (28.6%), pedal edema in 02 patients (28.6%), and dry cough in 03 patients (42.9%). Conclusion: Patients taking anti-hypertensive medications frequently encounter adverse drug reactions. Our study recommends regular ADR monitoring in hospital settings to encourage rational medication prescribing.
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Khan et al. (2026) conducted a cross-sectional in Hypertension (n=100). Antihypertensive drug therapy was evaluated on Adverse drug reactions (ADRs) and drug-related problems (DRPs). Antihypertensive therapy in 100 patients resulted in 7 suspected ADRs (3 dry cough, 2 pedal edema, 2 hyperkalemia) and 7 drug-related problems (4 medication non-receipt, 2 drug interactions).
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