Key result
Among 70 hypertensive primary care patients, adverse drug reactions to amlodipine included possible drowsiness (5.4%) and probable nausea (3.4%), while captopril was associated with definite dry cough (14.3%).
Why the study?
Non-compliance due to adverse reactions to antihypertensive drugs affects achieving blood pressure targets in primary care patients with hypertension.
Cross-Sectional (n=70)
No
Hypertension is one of the high-prevalence diseases in primary care. Failure to achieve the target of blood pressure is affected by non-compliance due to the antihypertensive adverse reactions. This study aims to determine adverse drug reaction (ADR) of antihypertensive drugs in primary care settings. A cross sectional study was conducted in “Sibela” Primary Care in Surakarta on March 2019. Investigators interviewed patients directly and observed supporting data from medical records. Hypertension patients with antihypertensive drugs at least for a month were eligible in this study. Then, the data were analyzed by the Liverpool algorithm that interpreted in 4 scales: unlikely, possible, probable, and definite. A total 70 subject were dominated by female (80%). Monotherapy of antihypertensive drugs prescribed to patient in primary care were amlodipine (80%) and captopril (10%). Nine events of ADR were found in hypertension patient. None ADR were doubtful. Possible ADR of amlodipine was drowsiness (5.4%), whereas probable ADR were nausea (3.4%), diuresis (1.8%), and abdominal pain (1.8 %). Definite ADR of captopril was dry mouth (14.3%) and probable ADR was abdominal pain (14.3%). Further investigation regarding the drowsiness, ADR of amlodipine, was needed.
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Farida et al. (2021) conducted a cross-sectional in Hypertension (n=70). Antihypertensive drugs (amlodipine, captopril) was evaluated on Incidence and causality of adverse drug reactions (ADRs) assessed by the Liverpool algorithm. Among 70 hypertensive primary care patients, adverse drug reactions to amlodipine included possible drowsiness (5.4%) and probable nausea (3.4%), while captopril was associated with definite dry cough (14.3%).
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