Key result
Tumour-adjacent catheter ablation successfully eliminates Purkinje-mediated ventricular tachycardia in paediatric cardiac rhabdomyoma.
Why the study?
Cardiac rhabdomyomas are associated with ventricular arrhythmias, but the underlying mechanisms remain uncertain.
Case Report (n=1)
This case demonstrates that a residual cardiac rhabdomyoma can anchor a localized Purkinje-mediated reentrant ventricular tachycardia, which can be successfully treated with catheter ablation at the tumor-adjacent site.
May inform ablation strategies in children with rhabdomyoma and Purkinje VT; leaves open generalizability from this single case.
Cardiac rhabdomyomas are associated with ventricular arrhythmias, but mechanisms remain uncertain. A 10-year-old boy with tuberous sclerosis complex developed verapamil-sensitive fascicular ventricular tachycardia adjacent to a residual cardiac rhabdomyoma. Electrophysiological mapping demonstrated Purkinje-mediated reentry. Catheter ablation at a tumour-adjacent site eliminated the arrhythmia, suggesting that residual rhabdomyoma may anchor a localised reentrant substrate.
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Izumi et al. (2026) conducted a case report in Verapamil-sensitive fascicular ventricular tachycardia with cardiac rhabdomyoma and tuberous sclerosis complex (n=1). Catheter ablation at a tumour-adjacent site was evaluated on Elimination of Purkinje-mediated ventricular tachycardia. Catheter ablation at a tumour-adjacent site eliminated Purkinje-mediated ventricular tachycardia in 1 child (10 years old) with a residual cardiac rhabdomyoma.
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