Hepatic AL amyloidosis can cause severe cholestasis independent of marrow tumor burden. In patients with absolute contraindications to high‐dose steroids—such as steroid‐induced psychosis—tailored daratumumab regimens with low‐dose corticosteroids can drive rapid, life‐saving organ reversal. However, intensive antimicrobial vigilance remains mandatory.
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Ceccarelli et al. (2026) studied this question.
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