Key result
Acute syncope is associated with an ~80% transient rise in mean BNP at 48 hours.
Why the study?
Brain natriuretic peptide may be a prognostic marker in syncope, and whether its levels change in association with an acute syncopal presentation needed to be established.
Does acute syncope presentation alter serial brain natriuretic peptide (BNP) levels over 4 weeks in hospitalized patients aged ≥60 years?
Cohort (n=31)
Does acute syncope presentation alter serial brain natriuretic peptide (BNP) levels over 4 weeks in hospitalized patients aged ≥60 years?
In older adults admitted with syncope, BNP levels transiently more than double between 18 hours and 1 week post-event before returning to baseline by 4 weeks, which has important implications for timing BNP measurement as a prognostic marker.
Transient post-syncope BNP rise may confound early prognostic use; leaves open whether delayed measurement refines risk stratification in older adults.
BACKGROUND: Brain natriuretic peptide (BNP) may be a good prognostic marker in syncope. The aim of this study was to establish whether there is any change in BNP in association with an acute presentation. METHODS: Patients aged ≥60 years admitted following presentation to the emergency department (ED) with syncope were eligible for prospective enrolment. Serial BNP measurements were performed on admission and at intervals up to 4 weeks after presentation. RESULTS: Between 8 March 2010 and 14 April 2010, 31 patients were recruited and were suitable for analysis, including seven patients who returned to the ED at 4 weeks. Mean BNP rose from a baseline of 167.8 ng/ml to a peak of 303.2 ng/ml at 48 h and then returned to baseline at 4 weeks. BNP ratio reached 2.3 (more than twice admission level) at 18 h and peaked at 2.4 at 1 week before returning to baseline at 4 weeks. CONCLUSIONS: BNP seems to rise from baseline to a peak between 18 h and 1 week after an acute syncopal episode in many patients. The reasons for this are not clear.
No takes yet. Share an insight, caveat, or question.
Matthew James Reed (2011) conducted a cohort in Syncope (n=31). Acute syncope presentation vs. Baseline admission level was evaluated on Serial brain natriuretic peptide (BNP) levels from admission up to 4 weeks. Acute syncope was associated with a transient rise in mean BNP from 167.8 ng/ml at baseline to 303.2 ng/ml at 48 h before returning to baseline at 4 weeks.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: