Key result
Cardiac troponins outperform conventional biomarkers for detecting myocardial injury and guiding therapy in ACS.
Why the study?
An increasing body of data suggests that measuring cardiac troponins can aid diagnosis, prognosis, and therapeutic decision-making in patients with acute coronary syndromes.
Does cardiac troponin measurement improve diagnosis, prognosis, and therapeutic decision-making in patients with acute coronary syndromes?
Does cardiac troponin measurement improve diagnosis, prognosis, and therapeutic decision-making in patients with acute coronary syndromes?
Answers are grounded in this paper and cite their sources.
Cardiac troponin I and T assays offer superior sensitivity and specificity over traditional cardiac enzymes for diagnosing myocardial infarction, risk-stratifying patients, and guiding antithrombotic therapy in acute coronary syndromes.
Cardiac troponins possess superior sensitivity and specificity for the detection of cardiac injury. They can be used successfully to replace measurements of MB isoenzyme of creatine kinase or lactate dehydrogenase for the retrospective diagnosis of myocardial infarction. Measurement of these proteins confers powerful prognostic information that can be used to triage patients. An increasing body of data suggests that measurement of troponin proteins can be useful to guide therapeutic decisions in patients with acute coronary artery syndromes, especially regarding treatment with low-molecular-weight heparin or IIB/IIIA inhibitors. The absence of troponins in the circulation does not necessarily indicate the absence of coronary artery disease. With current assays, a significant diagnostic difference does not appear to exist between cardiac troponin I and T in patients with acute coronary artery syndromes.
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Jesse E. Adams (1999) conducted a review in Acute coronary syndromes. Cardiac troponin I and T measurement vs. Creatine kinase-MB or lactate dehydrogenase measurement was evaluated on Detection of cardiac injury, risk stratification, and therapeutic guidance in acute coronary syndromes. Cardiac troponin I and T measurements provide superior sensitivity and specificity for detecting cardiac injury, offering prognostic value and guiding therapy in acute coronary syndromes.
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