Key result
Insulin resistance promotes cardiovascular disease via endothelial dysfunction, inflammation, and metabolic impairment.
Why the study?
Insulin resistance in metabolic syndrome promotes cardiovascular disease through impaired metabolism, endothelial dysfunction, and chronic inflammation, placing particular interest on calculated indices like the TyG index and METS-IR.
Highlights the role of insulin resistance and calculated indices such as the triglyceride-glucose (TyG) index and metabolic score for insulin resistance (METS-IR) in cardiovascular disease risk among individuals with metabolic syndrome.
Indices of insulin resistance may aid metabolic syndrome assessment; leaves open their predictive value for cardiovascular outcomes in prospective studies.
Metabolic syndrome is a significant risk factor for the cardiovascular system, with insulin resistance serving as one of the primary mechanisms of its development. Decreased tissue sensitivity to insulin is accompanied by impaired carbohydrate and lipid metabolism, endothelial dysfunction, and chronic inflammation, ultimately leading to the development of cardiovascular diseases. Current calculated indices of insulin resistance, including the triglyceride-glucose (TyG) index and the metabolic score for insulin resistance (METS-IR), are of particular interest.
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Yunusova S. Sh.2 Rakhmonova G.E.1 (2026) conducted a review in Metabolic syndrome and cardiovascular disease. Insulin resistance (including TyG index and METS-IR) was evaluated on Cardiovascular disease development. Insulin resistance in metabolic syndrome promotes cardiovascular disease via metabolic impairment, endothelial dysfunction, and inflammation, as assessed by TyG and METS-IR indices.
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