Key result
Comprehensive management of insulin resistance and metabolic syndrome prevents disease progression and CV risk.
Why the study?
Insulin resistance and metabolic syndrome are significant metabolic disorders globally associated with obesity, type 2 diabetes mellitus, cardiovascular diseases, and metabolic abnormalities.
This review summarizes current concepts on the pathophysiology, diagnosis, and management of insulin resistance and metabolic syndrome to reduce cardiovascular risk.
Emphasizes insulin resistance assessment in metabolic syndrome; leaves open optimal targets pending prospective trials.
Insulin resistance and metabolic syndrome are among the most significant metabolic disorders affecting global public health. These conditions are closely associated with obesity, type 2 diabetes mellitus, cardiovascular diseases, and various metabolic abnormalities. The present article examines contemporary concepts regarding the pathophysiological mechanisms, risk factors, diagnostic approaches, and treatment strategies related to insulin resistance and metabolic syndrome. Particular attention is given to the role of insulin resistance as a central factor in the development of metabolic syndrome and its complications. The article also discusses current preventive measures, including lifestyle modification and pharmacological interventions aimed at improving metabolic health and reducing cardiovascular risk. The findings highlight the importance of early diagnosis, comprehensive management, and evidence-based therapeutic approaches in preventing disease progression and improving long-term health outcomes
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Avazova et al. (2026) conducted a review in Insulin resistance and metabolic syndrome. Comprehensive management of insulin resistance and metabolic syndrome, including lifestyle and pharmacological interventions, is crucial for preventing disease progression and cardiovascular risk.
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