Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: NSAID consumption in the general population (n=4060). Intervention: Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin vs. Non-consumers or demographic/clinical reference subgroups (e.g., men vs. women, absence of cardiovascular disease). Primary outcome: Ever consumption of non-aspirin NSAIDs (women vs. men).

Q: What does this research mean for the field?

Non-aspirin NSAID consumption is higher in women and declines with age, whereas aspirin consumption is higher in men, increases with age, and is strongly linked to cardiovascular conditions without reducing non-aspirin NSAID use. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Inés Gómez‐Acebo; Trinidad Dierssen‐Sotos; María de Pedro; Beatriz Pérez‐Gómez; Gemma Castaño‐Vinyals; Tania Fernández‐Villa; Camilo Palazuelos; Pilar Amiano; Jaione Etxeberria; Yolanda Benavente; Guillermo Fernández‐Tardón; Inmaculada Salcedo‐Bellido; Rocío Capelo; Rosana Peiró; Rafael Marcos‐Gragera; José María Huerta; Adonina Tardón; Aurelio Barricarte; Jone Miren Altzibar; Jéssica Alonso-Molero; Verónica Dávila‐Batista; Núria Aragonés; Marina Pollán; Manolis Kogevinas; Javier Llorca

doi:10.1186/s12889-018-6019-z

Key result

Non-aspirin NSAIDs were consumed more by women (38.8%) than men (22.3%) and decreased with age, whereas aspirin consumption was higher in men (11.7% vs 5.2%) and in patients with cardiovascular risk.

Why the study?

NSAIDs are widely used despite their risks of gastrointestinal bleeding and cardiovascular events, warranting characterization of the demographic, behavioral, and cardiovascular profile of NSAID users in Spain.

Key Points

To evaluate the demographic factors, health-related behaviors, and cardiovascular disease history associated with NSAID and aspirin consumption across Spain.
A total of 4060 participants (2023 women and 2037 men) were selected using a pseudorandom number list from Family Practice registries across 12 Spanish provinces.
Participants completed a face-to-face computerized interview and self-administered questionnaires on NSAID use, demographics, body mass index, smoking, alcohol intake, and medical history.
Multivariate logistic regression analyses identified factors associated with ever and current NSAID consumption.
Women consumed more non-aspirin NSAIDs than men (38.8% [95% CI, 36.7-41.0] vs 22.3% [95% CI, 20.5-24.2]), whereas men used more aspirin than women (11.7% [95% CI, 10.3-13.2] vs 5.2% [95% CI, 4.3-6.3]).
Non-aspirin NSAID consumption declined with age from 44.2% (95% CI, 39.4-49.1) in those under 45 to 21.1% (95% CI, 18.3-24.2) in those older than 75, whereas aspirin use rose from 1.7% (<45 years) to 12.4% (≥75 years).
Aspirin was strongly linked to cardiovascular conditions, reaching odds ratios of 15.2 (95% CI, 7.4-31.2) in women with acute coronary syndrome, 13.3 (95% CI, 6.2-28.3) in women with stroke, and 11.1 (95% CI, 7.8-15.9) in men with acute coronary syndrome, while non-aspirin NSAID use did not decline among those with cardiovascular disease.

Study Design

Type

Cross-Sectional (n=4,060)

Multicenter

Yes

PICO

P

Population

4,060 adult population controls (mean age 62.9 years, 49.8% female, age range 22-85 years) randomly selected from general practice clinic lists across 12 Spanish provinces.

E

Exposure / Comparator

Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin vs Non-consumers or demographic/clinical reference subgroups (e.g., men vs. women, absence of cardiovascular disease)

O

Primary Outcome

Ever consumption of non-aspirin NSAIDs (women vs. men)

Main Result

Absolute Event Rate: 38.8% vs 22.3%

Limitations

Recall and social desirability bias from face-to-face interview without prescription validation
Potential underreporting of over-the-counter NSAIDs and aspirin
Sample consists of cancer-free controls from a case-control study, potentially biasing toward lower NSAID consumption than the general population
Potential self-selection bias among individuals agreeing to participate
Inability to distinguish whether aspirin was taken as a painkiller or for cardiovascular prevention

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Reveals distinct age and sex patterns in non-aspirin and aspirin NSAID consumption, highlighting persistent non-aspirin use among individuals with cardiovascular conditions.

Abstract

BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. METHODS: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression. RESULTS: Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4-49.1) in younger than 45 to 21.1% (18.3-24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (≥75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4-31.2) in women with acute coronary syndrome, 13.3 (6.2-28.3) in women with strokes and 11.1 (7.8-15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions. CONCLUSIONS: Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Gómez‐Acebo et al. (2018) conducted a cross-sectional in NSAID consumption in the general population (n=4,060). Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin vs. Non-consumers or demographic/clinical reference subgroups (e.g., men vs. women, absence of cardiovascular disease) was evaluated on Ever consumption of non-aspirin NSAIDs (women vs. men). Non-aspirin NSAIDs were consumed more by women (38.8%) than men (22.3%) and decreased with age, whereas aspirin consumption was higher in men (11.7% vs 5.2%) and in patients with cardiovascular risk.

synapsesocial.com/papers/6ae894d6f9b3831fffb85883 https://doi.org/10.1186/s12889-018-6019-z

View Full Paper

Ask AI

Bookmark

Share

Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

Key Points

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

Key Points

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading