Plasma Lipidvaluesin Obese Children

Q: What are the key findings of this study?

Exogenous childhood obesity was associated with significantly higher plasma total cholesterol (154.0 vs 126.8 mg/dL, p<0.01) and triglycerides (148 vs 83.8 mg/dL, p<0.01) compared to non-obese controls.

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Childhood obesity (n=67). Intervention: Exogenous childhood obesity vs. Healthy non-obese age-matched children (weight 25th-75th percentile). Primary outcome: Plasma total cholesterol (mg/dL) (p=<0.01).

Q: What does this research mean for the field?

Childhood obesity is associated with significantly elevated plasma triglycerides and total cholesterol compared to healthy, non-obese children. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To identify alterations in plasma lipid metabolism in obese children and evaluate the relationship between lipid profiles and hyperinsulinemia.

Berrak Sarıoğlu; Şule Can; Işın Yaprak; Ebru Özerkan; Savaş Kansoy; Sema Özinel

doi:10.5222/terh.1996.06464

January 1, 1996The Anatolian Journal of General Medical ResearchOpen Access

Plasma Lipidvaluesin Obese Children

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Key result

Childhood obesity is linked to ~27 mg/dL higher total cholesterol versus non-obese controls.

P<0.01
n=67

Why the study?

The study aimed to identify changes in lipid metabolism in obese children and evaluate their relationship with hyperinsulinemia.

Key Points

To identify alterations in plasma lipid metabolism in obese children and evaluate the relationship between lipid profiles and hyperinsulinemia.
Comparative cross-sectional study evaluated 47 obese children aged 5-14 years (BMI > 95th percentile, weight-for-age > 120%) and 20 age-matched non-obese healthy controls.
Plasma concentrations of triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1, and apolipoprotein B were measured alongside oral glucose tolerance tests.
Obese children had significantly higher plasma triglycerides (148±112 mg/dl vs 83.8±20.5 mg/dl, p<0.01) and total cholesterol (154.0±34.2 mg/dl vs 126.8±21.0 mg/dl, p<0.01) compared with non-obese controls.
No significant differences were identified between groups for apolipoprotein A1 (108.8±37.6 mg/dl vs 118.9±29.0 mg/dl, p>0.05) or apolipoprotein B (86.1±23.2 mg/dl vs 84.2±25.3 mg/dl, p>0.05).
Lipid parameters showed no significant differences between hyperinsulinemic (n=21) and normoinsulinemic (n=26) obese children (p>0.05 across all measured lipids).

Study Design

Type

Case-Control (n=67)

Multicenter

No

PICO

P

Population

67 children aged 5-14 years in Turkey (47 with exogenous obesity [BMI >95th percentile, weight for age >120%] and 20 age-matched healthy controls) evaluated cross-sectionally for plasma lipid profiles and hyperinsulinemia.

E

Exposure / Comparator

Exogenous childhood obesity vs Healthy non-obese age-matched children (weight 25th-75th percentile)

O

Primary Outcome

Plasma total cholesterol (mg/dL), p=<0.01

Main Result

Absolute Event Rate: 154% vs 126.8%

p-value: p=<0.01

Limitations

Small sample size (47 obese and 20 control children)
Apolipoprotein A1 and B measurements were only available for a subset of 27 obese children
Single-center observational design without longitudinal follow-up

Implication

Supports lipid evaluation in obese children; hypothesis-generating for insulin-independent mechanisms, needing prospective validation.

Abstract

Fortyseven obese children aged between 5-14 years were compared to 20 non-obese, healthy aged-matched children to identHy the changes in lipid metabolism.Body mass indexes of obese children were over 95th percentile and weight for age we:re over 120%.Plasma levels of triglycerides, total cholesterol, high-density lipopmtein cholesterol, lowdemıity lipoprotein cholesterol, apolipoprotein Aı, apolipoprotein B were assessed in boH'a groups and the ndationship between the results and hyperinsulinemia was evaluated.Triglycerides and total cholesterol were significantly higher in obese group (p<0,05).There was no correlation between groups according to high~density lipoprotein cholesterol, low~ density lipoprotein cholesterol, apolipoprotein Aı and apolipoprotein B Hype:rinsulinemic and normoinsulinemic obese children had also no differences in respect to lipid profile (p>0.05).In condusion, the study showed us that; however obesity is a risk factor for hyperlipidemia, plasma lipid levels we:re not affected at childhood as in aduHs.

Discussion

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Cite This Study

Sarıoğlu et al. (1996) conducted a case-control in Childhood obesity (n=67). Exogenous childhood obesity vs. Healthy non-obese age-matched children (weight 25th-75th percentile) was evaluated on Plasma total cholesterol (mg/dL) (p=<0.01). Exogenous childhood obesity was associated with significantly higher plasma total cholesterol (154.0 vs 126.8 mg/dL, p<0.01) and triglycerides (148 vs 83.8 mg/dL, p<0.01) compared to non-obese controls.

synapsesocial.com/papers/6ae8d3d2ab24e23977a824d7 https://doi.org/10.5222/terh.1996.06464

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Plasma Lipidvaluesin Obese Children

Key Points

Study Design

PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Plasma Lipidvaluesin Obese Children

Key Points

Study Design

PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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