Impaired Insulin Sensitivity and Elevated Ectopic Fat in Healthy Obese vs. Nonobese Prepubertal Children
Why the study?
Does obesity impair insulin sensitivity and increase ectopic fat deposition in healthy prepubertal children?
Population
123 healthy, exclusively prepubertal children, ethnically diverse.
Comparison
Obesity vs Nonobese
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
May indicate early cardiometabolic risk in obese prepubertal children; leaves open causal direction and need for longitudinal studies.
Structured PICO
Does obesity impair insulin sensitivity and increase ectopic fat deposition in healthy prepubertal children?
P
Population
123 healthy, exclusively prepubertal children (57 female, 66 male; mean age 8.04 ± 0.77 years), ethnically diverse.
I
Intervention
Obesity (age- and sex-adjusted BMI z-score ≥2, N=29)
C
Comparator
Nonobese (age- and sex-adjusted BMI z-score <2, N=94)
O
Outcome
Insulin sensitivity (assessed by S(i) and HOMA(IR)) and ectopic and visceral fat deposition (IMCL, IHL, VAT)surrogate
Excessive adiposity in prepubertal children is associated with significantly increased ectopic fat and insulin resistance, indicating early precursors of type 2 diabetes and metabolic syndrome.
Cite This Study
Bennett et al. (2011) studied this question.