Key result
Obese insulin-sensitive adolescents had lower intramyocellular (1.64% vs 2.26%, P=0.017) and visceral lipid deposition (45 vs 77 cm2, P=0.04) and higher adiponectin than insulin-resistant peers.
Why the study?
Is insulin sensitivity in obese adolescents associated with differences in lipid partitioning and adiponectin levels?
Population
28 obese adolescents with normal glucose tolerance, pair matched for age, gender, pubertal stage and body…
Design
Case-control
Authors
Loading...
/visceral), rather than total adiposity, may drive metabolic risk in obese youth.
Case-Control (n=28)
Is insulin sensitivity in obese adolescents associated with differences in lipid partitioning and adiponectin levels?
Absolute Event Rate: 1.64% vs 2.26%
p-value: p=0.017
In obese adolescents, insulin sensitivity is associated with lower intramyocellular and visceral lipid deposition and higher adiponectin levels despite similar adiposity.
Weiss et al. (2005) conducted a case-control in Obesity with normal glucose tolerance (n=28). Insulin sensitivity vs. Insulin resistance was evaluated on Intramyocellular lipid content (% of water peak) (p=0.017). Obese insulin-sensitive adolescents had lower intramyocellular (1.64% vs 2.26%, P=0.017) and visceral lipid deposition (45 vs 77 cm2, P=0.04) and higher adiponectin than insulin-resistant peers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: