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July 1, 1995AJP Endocrinology and Metabolism

Central adiposity and its metabolic correlates in obese adolescent girls

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Why the study?

Does central adiposity correlate with alterations in insulin action and secretion in obese adolescent girls?

Population

14 obese adolescent girls and 16 nonobese young women

Comparison

Assessment of insulin action via euglycemic… vs Nonobese young women

Design

Cross-sectional

Authors

SCSonia CaprioUniversity of SienaLHL. D. HymanYale UniversityCLCharles J. LimbUniversity of California, San Francisco

Discussion

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Implication

Visceral fat links to insulin resistance and hypersecretion in obese girls but should not change practice; hypothesis-generating for prospective studies on causality.

Structured PICO

Does central adiposity correlate with alterations in insulin action and secretion in obese adolescent girls?

P
Population
14 obese adolescent girls (mean age 13.2 +/- 0.7 years, BMI 32 +/- 1.4) and 16 nonobese young women (mean age 24.0 +/- 0.6 years, BMI 21.0 +/- 0.9)
I
Intervention
Assessment of insulin action via euglycemic insulin clamp, insulin secretion via hyperglycemic clamp, and fat depots via MRI
C
Comparator
Nonobese young women
O
Outcome
Insulin action, insulin secretion, and their relationship to body fat distributionsurrogate

Visceral fat, rather than subcutaneous fat or waist-to-hip ratio, strongly correlates with insulin resistance and hypersecretion in obese adolescent girls.

Cite This Study

Caprio et al. (1995) studied this question.

synapsesocial.com/papers/6a1a971f7ff99bba0645e968https://doi.org/10.1152/ajpendo.1995.269.1.e118
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differences at the Receptor and Postreceptor Levels Between Human Omental and Subcutaneous Adipose Tissue in the Action of Insulin on Lipolysis1983 · 290 citations
  2. 2Original Investigations Measurement of Fat Distribution by Magnetic Resonance Imaging1989 · 100 citations
  3. 3Splanchnic insulin metabolism in obesity. Influence of body fat distribution.1986 · 349 citations
  4. 4Correlation between muscle glycogen synthase activity and in vivo insulin action in man.1984 · 336 citations
  5. 5Colorimetric ultramicro method for the determination of free fatty acids1965 · 643 citations