Key result
Overweight status shows no difference in fat-free mass-corrected resting energy expenditure despite higher sympathovagal tone.
Why the study?
Alterations in the autonomic nervous system may impair metabolic processes and lead to weight gain, motivating an evaluation of differences in resting energy expenditure and resting autonomic activity between overweight/obese and normal-weight healthy subjects.
Does overweight/obesity alter resting energy expenditure corrected for fat-free mass and resting autonomic nervous system activity compared to normal weight in healthy subjects?
Cross-Sectional (n=38)
Does overweight/obesity alter resting energy expenditure corrected for fat-free mass and resting autonomic nervous system activity compared to normal weight in healthy subjects?
Resting energy expenditure corrected for fat-free mass is similar between overweight/obese and normal-weight individuals despite elevated sympathovagal balance in overweight/obese subjects, highlighting the need to adjust REE for fat-free mass to avoid misestimation.
Fat-free mass correction prevents REE misestimation in obesity; leaves open autonomic contributions to energy balance.
OBJECTIVE: Alterations in the autonomic nervous system (ANS) may cause impairment in the metabolic processes that can lead to weight gain. The purpose of this study was to determine the difference between the resting energy expenditure (REE) and the resting ANS activity in overweight/obese and normal-weight healthy subjects. METHOD: Group 1 consisted of 18 subjects with BMI > 25 kg/m², and 20 subjects with BMI ranging from 20 to 25 kg/m² formed group 2. Measurements of low-frequency (LF) and high-frequency (HF) power components expressed in normalized units (LFnu, HFnu) and LF/HF ratio were assessed for analysis of heart rate variability, and simultaneously REE measurement was performed. RESULTS: The mean LFnu (27.2% increased) and the LF/HF were higher and the mean HFnu was lower (29.9% decreased) in group 1 than in group 2 (p < 0.01). Although a statistical difference was observed in REE between groups, REE per kilogram corrected for fat-free mass (REE(FFMcorr)) was 21.47 ± 2.92 kcal/day/kg in group 1, and 21.56 ± 1.90 kcal/day/kg in group 2, and this difference was not statistically significant (p > 0.05). CONCLUSION: We concluded that REE(FFMcorr) in overweight/obese and normal-weight subjects were similar despite elevated sympathovagal balance in overweight/obese individuals, and REE(FFMcorr) should be used to avoid misestimating the REE in obese and normal-weight subjects.
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Dal et al. (2012) conducted a cross-sectional in Overweight/obesity (n=38). Overweight/obesity (BMI > 25 kg/m²) vs. Normal weight (BMI 20 to 25 kg/m²) was evaluated on Resting energy expenditure per kilogram corrected for fat-free mass (REE(FFMcorr)) (p=>0.05). Overweight/obese subjects had similar fat-free mass-corrected resting energy expenditure to normal-weight subjects (21.47 vs 21.56 kcal/day/kg, p>0.05) despite higher sympathovagal balance (p<0.01).
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