Pengaruh Konsentrasi Dan Pembilasan Terhadap Retensi Radioaktivitas Iodium-131 Cair Pada Syringe Dalam Penyiapan Radiofarmaka

Radioactivity retention in syringes during the preparation of liquid Iodine-131 radiopharmaceuticals may potentially reduce the prepared activity, cause radioactive contamination, decrease imaging quality, increase radioactive waste, and contribute to unwanted radiation exposure. This study aimed to evaluate the effects of concentration and rinsing on radioactivity retention of liquid Iodine-131 in syringes. An experimental study was conducted using liquid Iodine-131 at concentrations of 5, 10, and 15 mCi/mL. Initial and residual activities in the syringe were measured using a dose calibrator, while radiation exposure rate was measured using a gamma survey meter. The rinsing test was performed at a concentration of 15 mCi/mL using water for injection (WFI) and 0.9% NaCl as rinsing solutions in three sequential rinsing steps. Radioactivity retention increased with increasing concentration, with values of 12.90 ± 0.63%, 17.45 ± 0.68%, and 20.97 ± 0.74% at concentrations of 5, 10, and 15 mCi/mL, respectively. Radiation exposure rate also increased significantly. Rinsing significantly reduced radioactivity retention, while the type of rinsing solution used showed no significant difference. Concentration and rinsing affected radioactivity retention of liquid Iodine-131 in syringes