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“Sodium bicarbonate is commonly used clinically for in-hospital cardiac arrest, with administration in more than half of cardiac arrests in the [U.S.], suggesting that many clinicians consider sodium bicarbonate beneficial in this setting. Findings from this trial do not support this practice.”
“As noted, the trial was not powered for these outcomes and the results are uncertain. The 95% CIs for the risk ratio for 30-day survival ranged from 0.84 to 1.88 and for 30-day favorable neurological outcome from 0.82 to 2.34. As such, our results were compatible with harm, no effect, and benefit.”
DGDr. Georg GelbeneggerClinical Pharmacology
“BIHCA convincingly excluded a large effect on return of spontaneous circulation, but the trial was not powered for patient-centered outcomes. Although not statistically significant, all survival and neurological outcomes numerically favored sodium bicarbonate, including 30-day survival (12% vs 9.1%) and 30-day favorable neurological outcome (8.1% vs 5.4%).”
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Cite This Study
Andersen et al. (2026) studied this question.