Key result
Rituximab-based immunosuppressive therapy is linked to severe enteroviral encephalitis and polio-like paralysis.
Why the study?
Enteroviruses typically cause mild infections in childhood, but in immunocompromised patients they can lead to severe neurologic conditions such as encephalitis or polio-like paralysis.
Population
A patient with enteroviral T-cell encephalitis related to immunosuppressive therapy including rituximab
Answers are grounded in this paper and cite their sources.
May warrant vigilance for enteroviral neurologic disease in rituximab recipients; leaves open the relative contribution of specific agents.
Enteroviruses are a common cause of aseptic meningitis and mild infections in childhood. However, in immunocompromised patients they may cause severe neurologic conditions such as encephalitis or polio-like paralysis. Acknowledgment: The authors thank the patient and his family.
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Caldas et al. (2017) studied this question. Immunosuppressive therapy including rituximab can predispose patients to severe enteroviral neurologic conditions such as T-cell encephalitis or polio-like paralysis.
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