AMPK/USP10 loop activation of ACE2 in pulmonary hypertension: extending the cardiovascular-kidney-metabolic continuum to the pulmonary circulation?

Q: What does this research mean for the field?

AMPK/USP10 loop activation acts as a central hub for stabilizing ACE2 and preventing endothelial dysfunction, extending the cardiovascular-kidney-metabolic continuum to the pulmonary circulation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Irene Marthe Lang; Thomas A. Zelniker

doi:10.1093/eurheartj/ehag762

November 2, 2026European Heart JournalOpen Access

AMPK/USP10 loop activation of ACE2 in pulmonary hypertension: extending the cardiovascular-kidney-metabolic continuum to the pulmonary circulation?

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Key result

AMPK/USP10 loop activation serves as a central hub for ACE2 stability and the prevention of endothelial dysfunction in the pulmonary circulation.

Key Points

To examine the role of AMPK/USP10 loop activation in maintaining ACE2 stability and preventing endothelial dysfunction in pulmonary circulation.
Conceptual and mechanistic pathway synthesis analyzing AMPK/USP10 signaling interactions with ACE2 within pulmonary vascular endothelial cells.
Identifies AMPK/USP10 loop activation as a central regulatory hub necessary for maintaining ACE2 stability.
Shows that sustaining ACE2 through this loop prevents endothelial dysfunction, integrating pulmonary circulation into the broader cardiovascular-kidney-metabolic continuum.

Design

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Implication

Highlights the role of AMPK/USP10 loop activation in stabilizing ACE2 and preventing endothelial dysfunction within the pulmonary circulation as part of the cardiovascular-kidney-metabolic continuum.

Abstract

The cardiovascular-kidney-metabolic continuum includes the pulmonary circulation, with AMPK/USP10 loop activation as a central hub (white box in the middle of the figure) for ACE2 stability and prevention of endothelial dysfunction.

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Cite This Study

Lang et al. (2026) studied this question. AMPK/USP10 loop activation serves as a central hub for ACE2 stability and the prevention of endothelial dysfunction in the pulmonary circulation.

synapsesocial.com/papers/6aea772189a8acbed9c87aef https://doi.org/10.1093/eurheartj/ehag762

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AMPK/USP10 loop activation of ACE2 in pulmonary hypertension: extending the cardiovascular-kidney-metabolic continuum to the pulmonary circulation?

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

AMPK/USP10 loop activation of ACE2 in pulmonary hypertension: extending the cardiovascular-kidney-metabolic continuum to the pulmonary circulation?

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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