Key result
AMP-activated protein kinase (AMPK) acts as a core signaling pathway in the heart, regulating energy metabolism, protecting against ischemic injury, and limiting cardiac myocyte hypertrophy.
Design
Review
Authors
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May support AMPK-targeted therapies in ischemia and hypertrophy; leaves open need for clinical trials to confirm benefit.
AMPK is a crucial signaling pathway in cardiac metabolism and pathology, presenting a potential therapeutic target for myocardial ischemia and hypertrophy.
Kim et al. (2009) conducted a review in Cardiac metabolism and disease. AMP-activated protein kinase (AMPK) was evaluated. AMP-activated protein kinase (AMPK) acts as a core signaling pathway in the heart, regulating energy metabolism, protecting against ischemic injury, and limiting cardiac myocyte hypertrophy.
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