Key result
Complementary medicines alter warfarin anticoagulation, warranting INR retesting within ~1 week.
Why the study?
Many complementary medicines have confirmed or potential interactions with warfarin, a drug with a narrow therapeutic window, which can alter its anticoagulant effect and cause serious adverse events.
Answers are grounded in this paper and cite their sources.
May warrant closer INR surveillance with complementary medicines in warfarin users; leaves open quantification of interaction risks in prospective trials.
Many complementary medicines have confirmed or potential interactions with warfarin. These interactions can increase or decrease the anticoagulant effect of warfarin and have the potential to cause serious adverse events. A number of herbs and foods alter the metabolism of warfarin by acting on cytochrome P450 enzymes. Other potentially interacting complementary medicines include those with possible effects on platelets and those containing natural coumarins. Warning both consumers and prescribers of warfarin about the potential for interactions with complementary medicines may reduce the risk of these interactions. Such warnings are appropriate for a drug that has a narrow therapeutic window and requires regular monitoring. In view of these interactions, prescribers should check the international normalised ratio within a week of a patient commencing or ceasing a complementary medicine.
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Stephen P Myers (2002) conducted a review in Anticoagulation therapy with warfarin. Complementary medicines concurrent with warfarin was evaluated on Altered anticoagulant effect of warfarin and serious adverse events. Complementary medicines can alter warfarin's anticoagulant effect, requiring INR monitoring within 1 week of starting or stopping them.
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